Targeting SIRT1 to improve metabolism: all you need is NAD+?

Written by
Carles Canto
Published on
August 30, 2021 at 3:47:00 PM PDT August 30, 2021 at 3:47:00 PM PDTth, August 30, 2021 at 3:47:00 PM PDT

Authors: Carles Cantó and Johan Auwerx


Nicotinamide adenine dinucleotide (NAD+) metabolism is integrally connected with the mechanisms of action of radiation therapy and is altered in many radiation-resistant tumors. This makes NAD+ metabolism an ideal target for therapies that increase radiation sensitivity and improve patient outcomes. This review provides an overview of NAD+ metabolism in the context of the cellular response to ionizing radiation, as well as current therapies that target NAD+ metabolism to enhance radiation therapy responses. Additionally, we summarize state-of-the-art methods for measuring, modeling, and manipulating NAD+ metabolism, which are being used to identify novel targets in the NAD+ metabolic network for therapeutic interventions in combination with radiation therapy.

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